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Introduction: Amenorrhea, defined as the absence of menstruation, is a condition with multiple etiologies, ranging from physiological states to pathological disorders. Ayurveda describes this condition as Nashtartava, which is often considered a symptom as well as a disease entity under Yonivyapad and Artava-dushti. The classical texts provide detailed explanations of causative factors, pathogenesis, and management strategies that integrate diet, lifestyle, and therapeutic interventions. Methods: A systematic review of Ayurvedic texts (Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya, Kashyapa Samhita), classical commentaries, and Nighantus was undertaken to compile references on Nashtartava. Additionally, an electronic search was performed on PubMed, Scopus, Web of Science, and Google Scholar using the terms “Amenorrhea,” “Nashtartava,” “Ayurveda,” and “Artava-dushti” between 2000–2025. Clinical trials, observational studies, and review articles were included. Results: Ayurveda attributes Nashtartava primarily to vitiation of Vata dosha, with contributory roles of Kapha and Pitta. Causative factors include improper diet, excessive exertion, psychological disturbances, and reproductive tract disorders. Management is based on correcting Vata imbalance through Snehana, Swedana, Basti karma, and Rasayana therapy, alongside use of specific herbs such as Shatavari, Ashoka, Lodhra, and Kumari. Modern research highlights the role of nutritional deficiencies, hypothalamic-pituitary-ovarian axis dysfunction, and lifestyle stressors in amenorrhea, aligning with Ayurvedic insights. Discussion: Ayurveda emphasizes individualized treatment focusing on dosha balance and Agni correction, which resonates with modern integrative approaches involving diet, stress management, and hormonal regulation. However, evidence from clinical trials validating Ayurvedic interventions remains limited, necessitating more robust studies. Conclusion: The concept of Nashtartava provides a holistic framework for understanding and managing amenorrhea. Integration of Ayurvedic principles with modern gynecological insights may enhance therapeutic outcomes and support women’s reproductive health.

KEYWORDS: Amenorrhea, Artava-dushti, Ayurveda, Nashtartava, Women’s health, Women’s health