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Introduction: Infertility is a major global health concern, affecting nearly 10–15% of couples. Ayurveda attributes infertility to vitiation of doshas and derangement of shukra dhatu, along with uterine and systemic factors. Phalatrikadi Kwath, a classical Ayurvedic polyherbal decoction, is traditionally prescribed for gynecological disorders, garbhasthapana (maintenance of pregnancy), and enhancement of fertility. Despite its frequent use in clinical practice, comprehensive evidence-based evaluation is limited. Methods: A literature search was conducted across Ayurvedic classical texts, PubMed, Scopus, Web of Science, and Google Scholar. Inclusion criteria comprised classical references, experimental pharmacological studies on constituent herbs, and clinical studies (open-label, observational, randomized controlled trials) evaluating Phalatrikadi Kwath or its ingredients in infertility and related reproductive disorders. Exclusion criteria included non-scientific reports, unpublished theses, and studies unrelated to fertility outcomes. Results: Classical Ayurvedic literature identifies Phalatrikadi Kwath as a potent formulation for yonivyapad (gynecological disorders), vandhyatva (infertility), and garbhasthapana. Modern pharmacological research on its key ingredients (Haritaki, Bibhitaki, Amalaki, Musta, Amruta, Guduchi, Vasa, etc.) demonstrates antioxidant, adaptogenic, uterine tonic, and gonadotropic effects, which support ovulation, endometrial receptivity, and sperm quality. Limited but promising clinical studies report improved conception rates, hormonal balance, and reduced oxidative stress with formulations containing these herbs. Discussion: Integrating Ayurvedic principles with biomedical perspectives, Phalatrikadi Kwath shows potential as a supportive therapy in infertility management. However, gaps remain regarding standardized dosage, pharmacokinetics, long-term safety, and large-scale randomized trials. Conclusion: Phalatrikadi Kwath holds promise in infertility management by synergistically correcting systemic imbalances and enhancing reproductive potential. Further well-designed clinical research is essential to establish its efficacy and integrate it into evidence-based infertility care.

KEYWORDS: Ayurveda, Fertility, Infertility, Phalatrikadi Kwath, Reproductive Health